We screened 115 children with Down syndrome for celiac disease, using
antigliadin, antiendomysium, and antireticulin serum antibodies and an
intestinal permeability test, Celiac disease was diagnosed in eight c
hildren, giving a frequency of 7.0%. We recommend screening for celiac
disease in all persons with Down syndrome, with the use of at least t
he antiendomysium antibody determination.