R. Thiagarajan et al., HYPONATREMIA CAUSED BY A RESET OSMOSTAT IN A NEONATE WITH CLEFT-LIP AND PALATE AND PANHYPOPITUITARISM, The Journal of pediatrics, 128(4), 1996, pp. 561-563
A neonate with cleft lip and palate and hypopituitarism had persistent
hyponatremia despite treatment with hydrocortisone, L-thyroxine, and
growth hormone. Serum sodium concentration and urinary osmolality incr
eased and decreased appropriately and concurrently with alterations in
sodium and water intake, The ability to regulate serum concentrations
of antidiuretic hormone at subnormal serum sodium concentrations indi
cated a reset osmostat.