Dg. Mccarvermay et al., COMPARISON OF CHLORAL HYDRATE AND MIDAZOLAM FOR SEDATION OF NEONATES FOR NEUROIMAGING STUDIES, The Journal of pediatrics, 128(4), 1996, pp. 573-576
In a crossover study of seven term neonates who had neuroimaging studi
es, chloral hydrate (75 mg/kg administered orally) was more efficaciou
s (p < 0.05) but similar with regard to toxic effects than midazolam (
0.2 mg/kg administered intravenously), Thus newer drugs are not necess
arily better, and monitoring is essential even after a single oral sed
ative dose.