FLUCONAZOLE-RESISTANT CANDIDA-ALBICANS AFTER LONG-TERM SUPPRESSIVE THERAPY

Candida albicans is generally considered to be susceptible, in vivo, t o fluconazole. In the population infected with human immunodeficiency virus, recurrent bouts of oral and esophageal candidiasis have led to increasing use of fluconazole for long-term prophylaxis. With prolonge d therapy, the issue of developing resistance emerges. We report a cas e of fluconazole-resistant C albicans esophagitis that developed after fluconazole was used for more than 600 days.