DISPERSION OF CHROMOGRANIN SECRETOGRANIN SECRETORY PROTEIN FAMILY LOCI IN MAMMALIAN GENOMES

Chromogranin A, chromogranin B, and secreto-granin II, members of the chromogranin/secretogranin secretory protein family, are overexpressed in some human hereditary maladies and may have arisen, in part, from common ancestor genes. To understand better the mammalian chromosomal dispersion of this gene family and to facilitate studies of these gene s in human illnesses and their animal models, we positioned the locus of each member in the rat, mouse, and human genomes. Our results indic ate that each locus lies in a region of locally syntenic chromosomal h omology across the three species. (C) 1996 Academic Press, Inc.