We report a case of unusual B-cell malignant lymphoma of the kidney an
d mediastinum. Renal biopsy showed prominent myxoid changes and sarcom
atous features, leading to considerable difficulty in histologic diagn
osis on routinely stained histologic sections. However, immunohistoche
mical staining for lymphocyte markers led to the final histologic diag
nosis of B-cell malignant lymphoma. Although myxoid change is not gene
rally found in malignant lymphoma, malignant lymphoma should not be ex
cluded from consideration when one encounters a small round cell sarco
ma with myxoid stroma, especially in extranodal soft tissue tumors.