HEREDITARY SERUM-CHOLINESTERASE DEFICIENCY ASSOCIATED WITH SEVERE LIPID DEPOSITION IN THE KIDNEY

A 47-year-old woman who was homozygous for a silent cholinesterase gen e (hereditary serum cholinesterase deficiency) presented with nephroti c syndrome and hyperlipidemia. Renal biopsy performed in 1986 demonstr ated mesangial proliferative glomerulonephritis. Four years later, a s econd biopsy revealed progression with mesangial interpositions and se vere lipid deposition in the glomeruli, tubules and interstitium. This is the first case of hereditary serum cholinesterase deficiency accom panied by renal disease. Serum cholinesterase deficiency may be relate d to hyperlipidemia and abnormal lipid deposition in the kidney, which promotes the progression of renal disease.