Aj. Carrilomunoz et al., IN-VITRO ANTIFUNGAL ACTIVITY OF SERTACONAZOLE, BIFONAZOLE, KETOCONAZOLE, AND MICONAZOLE AGAINST YEASTS OF THE CANDIDA GENUS, Journal of antimicrobial chemotherapy, 37(4), 1996, pp. 815-819
The in-vitro antifungal activity of sertaconazole against 110 strains
of Candida yeasts (50 Candida albicans, 15 Candida glabrata, 2 Candida
guilliermodii, 8 Candida krusei, 1 Candida kefyr, 8 Candida parapsilo
sis and 26 Candida tropicalis) was assessed in comparison with bifonaz
ole, ketoconazole, econazole and miconazole. The majority of the strai
ns were clinical isolates; some reference strains were included. A com
mercial agar diffusion method (NeoSensitabs, Rosco, Taastrup, Denmark)
in Shadomy's modified medium pH 7 was used. Using the manufacturer's
criteria, 86.4% of the strains were classified as ''sensitive'' to ser
taconazole. The only strain classified as ''resistant'' to sertaconazo
te was the control reference strain of C. albicans. The remaining stra
ins were classified as ''moderately sensitive''. The sensitivity/resis
tance percentages for the other antifungals tested were 75.5/1.8 for k
etoconazole, 71.8/2.7 for miconazole, 63.7/13.6 for econazole, and 59.
1/5.5 for bifonazole. Sertaconazole showed a higher antifungal activit
y than that of the other antimycotics, tested in vitro which was stati
stically significant (P < 0.001), as well as a lower resistance rate t
han that of econazole, bifonazole and ketoconazole.