CONCENTRATIONS OF CEFPODOXIME IN PLASMA, ADENOID, AND TONSILLAR TISSUE AFTER REPEATED ADMINISTRATIONS OF CEFPODOXIME PROXETIL IN CHILDREN

Cefpodoxime proxetil was administered to 36 children undergoing tonsil lectomy, adenoidectomy or both. It was very well tolerated. The detect able tissue concentrations of cefpodoxime were moderate but remained c onstant (approximately 0.05 mg/kg) 3, 6, and 12 h after the last dose of the drug, while the respective plasma concentrations were declining . This suggests the possibility of twice-daily administration. However , 30% of children did not have quantifiable concentrations in the tons il and more than half the adenoids did not have quantifiable levels. W hether a higher dosage would lead to higher and more satisfactory tiss ue concentrations is a matter for further investigation.