Ba. Kowalczyk et al., IMPROVED PREPARATION OF (R)-3-AMINOQUINUCLIDINE AND (S)-3-AMINOQUINUCLIDINE DIHYDROCHLORIDE, Synthetic communications, 26(10), 1996, pp. 2009-2015
An improved procedure for the synthesis of either (R) or (S)-3-aminoqu
inuclidine was developed. Key intermediate imine 2 was made in a one p
ot process using lithium oxide as the base and molecular sieves.