HEMODYNAMIC IN PATIENTS WITH ARTERIAL-HYP ERTENSION IN STAMINA (RUNNING) OR NIFEDIPIN TREATMENT

This is a report about the therapeutic behavior of blood pressure and heart rate in patients suffering from hypertension. Forty male patient s with hypertension (age: 30-53 years) were treated either with runnin g or swimming therapy according to the stamina principle or with nifed ipine therapy (40-60 mg/d). Both groups were randomized. Peripherical hemodynamics were investigated by means of the Xenon-133-muscle-cleara nce (M. tibialis anterior). The values of interest were half-value tim e (T1/2) and the mean functional vessel diameter. Additionally total p eripherical vascular resistance (TPR) and radiocardiographic cardiac o utput (GO) were measured. Significant decrease of systolic and diastol ic blood pressure values at rest were obtained with the therapeutic re gimens. CO increased and the TPR decreased. The decrease of blood pres sure during physical therapy and with nifedipine therapy also is due t o the enhanced microcirculation. Half-value time of muscle clearance ( T1/2) and the mean functional vascular diameter were increased signifi cantly.