Iag. Desegura et al., COMPARATIVE EFFECTS OF GROWTH-HORMONE IN LARGE AND SMALL-BOWEL RESECTION IN THE RAT, The Journal of surgical research, 62(1), 1996, pp. 5-10
Our aim was to assess the proliferative effect of human growth hormone
on ileal mucosa after two different adaptation models of massive smal
l and massive large bowel resection. Male Wistar rats were assigned to
control-laparotomy, 90% small bowel resection, or 75% large bowel res
ection and were treated with either saline or human growth hormone dai
ly for 7 days (total six groups; n = 8/group). Heal proliferative stat
us was assessed by means of histomorphometry and proliferating cell nu
clear antigen. Plasma somatostatin was quantitated. Growth hormone inc
reased (P < 0.01) mucosal height in all groups with a more marked effe
ct on the crypt than on villus height. Proliferating cell nuclear anti
gen-labeled cells increased similarly (P < 0.01). Small bowel resectio
n appears to favor a more marked increment in villus height than large
bowel resection. Compared to control saline-treated group, the remain
ing groups showed decreases in plasma somatostatin (P < 0.01). Human g
rowth hormone has a marked trophic effect on intestinal mucosa, even i
n hyperproliferative states. Decreased plasma somatostatin associated
with intestinal hyperplastic mucosa suggests a possible relationship w
ith the adaptive process. (C) 1996 Academic Press, Inc.