IN-VITRO EVALUATION OF PECTIN-BASED COLONIC DRUG-DELIVERY SYSTEMS

Pectin-based dosage forms with the potential for site-specific deliver y to the colon have been evaluated using isolated enzymes and cultures of Bacteroides ovatus. The system used was designed and validated to allow systematic testing of colonic dosage forms which depend on the a ction of colonic bacteria for drug release. Preliminary experiments sh ow the similarity in release patterns for the dosage form tested with isolated enzymes and bacterial cultures. This should enable further ex periments to be performed to ascertain valid in vitro testing conditio ns.