FISH LOCALIZATION OF THE SOLUBLE THYMIDINE KINASE GENE (TK1) TO HUMAN17Q25, A REGION OF CHROMOSOMAL LOSS IN SPORADIC BREAST-TUMORS

Authors
PETTY EM MILLER DE GRANT AL COLLINS EE GLOVER TW LAW DJ
Citation
Em. Petty et al., FISH LOCALIZATION OF THE SOLUBLE THYMIDINE KINASE GENE (TK1) TO HUMAN17Q25, A REGION OF CHROMOSOMAL LOSS IN SPORADIC BREAST-TUMORS, Cytogenetics and cell genetics, 72(4), 1996, pp. 319-321
Citations number
15
Categorie Soggetti
Cell Biology","Genetics & Heredity
Journal title
Cytogenetics and cell genetics → ACNP
ISSN journal
03010171
Volume
72
Issue
4
Year of publication
1996
Pages
319 - 321
Database
ISI
SICI code
0301-0171(1996)72:4<319:FLOTST>2.0.ZU;2-#
Abstract
Soluble thymidine kinase (TK1) is an important 17q marker in somatic c ell genetics. Its activity is increased in many malignancies, includin g breast cancer. Through somatic cell hybrid and fluorescence in situ hybridization studies, we mapped TK1 to 17q25.2-->q25.3, in a region d emonstrating loss of heterozygosity in primary breast tumors. It lies near D17S836 and is proximal to the avian erythroblastic leukemia vira l oncogene homolog 2-like gene (ERBA2L).