Em. Petty et al., FISH LOCALIZATION OF THE SOLUBLE THYMIDINE KINASE GENE (TK1) TO HUMAN17Q25, A REGION OF CHROMOSOMAL LOSS IN SPORADIC BREAST-TUMORS, Cytogenetics and cell genetics, 72(4), 1996, pp. 319-321
Soluble thymidine kinase (TK1) is an important 17q marker in somatic c
ell genetics. Its activity is increased in many malignancies, includin
g breast cancer. Through somatic cell hybrid and fluorescence in situ
hybridization studies, we mapped TK1 to 17q25.2-->q25.3, in a region d
emonstrating loss of heterozygosity in primary breast tumors. It lies
near D17S836 and is proximal to the avian erythroblastic leukemia vira
l oncogene homolog 2-like gene (ERBA2L).