XENOTRANSPLANTATION

This paper describes the rationale behind the need for xenotransplanta tion and the physiological and immunological barriers associated with xenografting from pig to man. The scientific strategies developed for overcoming the immunological barriers associated with hyperacute rejec tion are described in detail as is the technology for producing transg enic pigs. Data on perfusion studies of transgenic pig hearts with hum an blood demonstrates the validity of this scientific approach.