COMPARISON OF MIB-1 (KI-67) ANTIGEN AND BROMODEOXYURIDINE PROLIFERATION INDEXES IN MENINGIOMAS

Meningiomas from 40 adult patients were labeled immunohistochemically with monoclonal antibodies to bromodeoxyuridine (BUdR) and the Ki-67 a ntigen, MIB-1. The meningiomas were classified as classical, or benign (n = 31); atypical (n = 4); or malignant (n = 5). Meningeal sarcomas and hemangiopericytomas were excluded. The patient population consiste d of 26 women and 14 men, ranging in age from 26 to 75 years. BUdR pro liferation indices ranged from 0% to 5.8%, measurements that were expe ctedly lower than those for MIB-1, which ranged from 1.5% to 19.3%. MI B-1 proliferation indices were not significantly affected regarding st eroid pretreatment or age. These results show a good correlation betwe en the BUdR and MIB-1 proliferation markers (r(s) = 0.72; P < .0001), which supports the use of anti-MIB1 as an alternative labeling tool to BUdR for the determination of the proliferation index in meningiomas, thus avoiding the administration of a potentially mutagenic drug. (C) 1996 by W.B. Saunders Company