TOTAL LEUKODERMA - A RARE MANIFESTATION OF CUTANEOUS CHRONIC GRAFT-VERSUS-HOST DISEASE

Authors
NAGLER A GOLDENHERSH MA LEVISCHAFFER F BYSTRYN JC KLAUS SN
Citation
A. Nagler et al., TOTAL LEUKODERMA - A RARE MANIFESTATION OF CUTANEOUS CHRONIC GRAFT-VERSUS-HOST DISEASE, British journal of dermatology, 134(4), 1996, pp. 780-783
Citations number
16
Categorie Soggetti
Dermatology & Venereal Diseases
Journal title
British journal of dermatology → ACNP
ISSN journal
00070963
Volume
134
Issue
4
Year of publication
1996
Pages
780 - 783
Database
ISI
SICI code
0007-0963(1996)134:4<780:TL-ARM>2.0.ZU;2-6
Abstract
We describe a 14-year-old boy who developed total leucoderma during th e course of chronic graft-versus-host disease, which developed after a llogeneic bone marrow transplantation. Skin biopsy and dihydroxy-pheny lalanine staining revealed a total absence of melanocytes from the epi dermis. Cytotoxic anti-melanocyte antibodies were found in the patient 's serum, and this probably explains the development of the leucoderma .