CHRONOTHERAPY OF PATIENTS WITH EFFORT ANG INA-PECTORIS BY METOPROLOL

Two groups of patients with stable effort angina (functional class II - III) were treated by metoprolol. In group 1 principle of chronothera py was employed which meant consideration of chronosensitivity to a dr ug. Chronosensitivity to metoprolol was determined on the basis of cli nico-pharmacological studies conducted during 4 days. Main hemodynamic parameters were obtained before and in 30 and 60 minutes and 3 hours after a single dose of 100 mg of metoprolol taken at different times o f the 24 hour period. Then metoprolol (100 mg orally) was given once a day at the time of maximal sensitivity to the drug. Patients of the g roup II received metoprolol twice a day with equal fixed intervals bet ween takings. Analysis of results demonstrated advantages of schedulin g metoprolol dosages according to chronosensitivity to the drug.