N-6-BENZYLADENOSINE ANALOGS OF (A2'P)(2)A - SYNTHESIS AND ACTIVITY TOTOBACCO MOSAIC-VIRUS

Authors
KVASYUK EI KULAK TI ZINCHENKO AI BARAI VN MIKHAILOPULO IA
Citation
Ei. Kvasyuk et al., N-6-BENZYLADENOSINE ANALOGS OF (A2'P)(2)A - SYNTHESIS AND ACTIVITY TOTOBACCO MOSAIC-VIRUS, Bioorganiceskaa himia, 22(3), 1996, pp. 208-214
Citations number
29
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Bioorganiceskaa himia → ACNP
ISSN journal
01323423
Volume
22
Issue
3
Year of publication
1996
Pages
208 - 214
Database
ISI
SICI code
0132-3423(1996)22:3<208:NAO(-S>2.0.ZU;2-K
Abstract
Analogs of (2'-5')oligoadenylate trimer with N-6-benzyladenosine in va rious positions of the chain and the fully-substituted trimer were syn thesized by the phosphotriester method. The structures of compounds pr epared were proved by UV, CD, and H-1 NMR. The obtained substances inh ibit replication of tobacco mosaic virus at 10(-8)-10(-6) M concentrat ion, which is comparable with that of natural (A2'p)(2)A triadenylate.