INFLUENCE OF NMDA RECEPTOR ANTAGONIST (+ -)-CPP ON THE CONDITIONED ACTIVATION OF THE OPERANT RESPONSE IN THE TEST OF INTRACRANIAL SELF-STIMULATION IN RATS/

Authors
BESPALOV AY ZVARTAU EE
Citation
Ay. Bespalov et Ee. Zvartau, INFLUENCE OF NMDA RECEPTOR ANTAGONIST (+ -)-CPP ON THE CONDITIONED ACTIVATION OF THE OPERANT RESPONSE IN THE TEST OF INTRACRANIAL SELF-STIMULATION IN RATS/, Zurnal vyssej nervnoj deatelnosti im. I.P. Pavlova, 46(1), 1996, pp. 117-121
Citations number
23
Categorie Soggetti
Physiology,Neurosciences
Journal title
Zurnal vyssej nervnoj deatelnosti im. I.P. Pavlova → ACNP
ISSN journal
00444677
Volume
46
Issue
1
Year of publication
1996
Pages
117 - 121
Database
ISI
SICI code
0044-4677(1996)46:1<117:IONRA(>2.0.ZU;2-D
Abstract
Self-stimulation behaviour was studied in rats with implanted bipolar electrodes in ventral tegmental area (VTA) and guide cannulae in nucle i accumbens septi (NAC). Conditioned activation of the operant respons e was induced by the stimuli associated with rewarding electrical stim ulation of VTA, i. e., light or subthreshold stimulation. Bilateral ad ministration of NMDA receptor antagonist (+/-)-CPP (2.5 mcg in each ca nnula) significantly attenuated the facilitating effect of the conditi oned stimuli. These data provide evidence for the role of glutamatergi c transmission in NAC in realization of responses with conditioned rei nforcement.