COMPARATIVE-ANALYSIS OF THE EFFECTS OF SY STEMIC AND INTRACEREBROVENTRICULAR INJECTIONS OF SEROTONIN ANTIBODIES ON BEHAVIORAL REACTIONS ANDNOCICEPTIVE SENSITIVITY IN ANNALS

The antibodies to serotonin modulate behavioural reactions of animals depending on the mode of administration (intracerebroventricular or in traperitoneal) and the testing time. Intraventricular injection induce s inhibition of behavioural activity within 1-2 hours. Systemic inject ion produces a biphasic effect on the serotoninergic system, i. e., th e activation in the early period and the steady inhibition later. Effe cts of the intraperitoneally injected serotonin antibodies on the CNS are probably mediated either by serotonin binding in blood or by invol vement of neurotrophic factors of the immune system. Both ways of admi nistration of the serotonin antibodies. result in late hyperalgesia.