IS THERE A DEPENDENCE BETWEEN THE COMPLIC ATION RATE AFTER GENETIC AMNIOCENTESIS AND INDICATIONS FOR INTERVENTIONS - ASSESSMENT OF 2066 PUNCTURES

Data from 2066 amniocenteses were analysed retrospectively to test the hypothesis whether the indications for amniocentesis influence the ri sk of post-procedural complications. Compared to the reference group o f 35-39 year-old gravidae, the complication rates were similar in wome n with a previous child with chromosomal abnormality, in cases with ma ternal disease, abnormal biochemical markers, maternal anxiety, and tr anslocation carriers. If the maternal age was 40 years and over, only the percentage of pregnancy terminations for fetal abnormalities was h igher than in the reference group; high parental age was associated wi th a significantly decreased fetal loss rate. In the group of amniocen teses performed for sonographic evidence of fetal malformation, the hi ghest total complication rates and the highest fetal loss rates were o bserved.