Gc. Sahoo et al., FACILITATED TRANSPORT OF 7-AMINOCEPHALOSPORANIC ACID IN A BULK LIQUIDMEMBRANE, Journal of membrane science, 112(2), 1996, pp. 147-154
7-Aminocephalosporanic acid (7-ACA) was transported from a dilute aque
ous solution through a bulk liquid membrane containing Aliquat-336 as
a carrier dissolved in butyl acetate as the solvent to another aqueous
solution of lower pH. The transport is based on the pH dependant dist
ribution coefficient of 7-ACA, which is defined as the ratio of the eq
uilibrium concentration of 7-ACA in the organic membrane phase to that
in the aqueous phase. Thus, by maintaining a pH gradient between the
feed and stripping phases, 7-ACA transport could be facilitated. The c
ounter transport of chloride ion favours facilitated transport, but a
limiting Cl- concentration exists beyond which the stripping rate is d
ecelerated. The results of experiments in a stirred transfer cell coul
d be interpreted from a simple mass transfer model developed on the ba
sis of the overall rate dependant on diffusion of the 7-ACA anions at
the interfaces and membrane liquids.