PHARMACOLOGICAL PROFILE OF IOBITRIDOL, A NONIONIC IODINATED CONTRAST-MEDIUM

The present article combines and summarizes the preclinic studies carr ied out in vitro and in vivo to determine the pharmacologic and bioche mical profile of iobitridol, a new nonionic iodinated low-osmolality c ontrast medium (CM). The effects of this product on the main hemodynam ic, bronchopulmonary, neurologic, renal, blood chemistry and electroph ysiologic parameters and RBC morphology were studied in detail in comp arison with CM in the same chemical category or with reference substan ces of the same osmolality. The in vivo studies were performed under c onditions resembling clinical use. Iobitridol showed an excellent phar macologic and biochemical profile, which was identical or superior to that of other products in its category.