H. Felix et al., IMMUNOHISTOCHEMICAL AND ELECTROPHYSIOLOGICAL DEMONSTRATION OF SUBSTANCE-P IN HUMAN VESTIBULAR GANGLION-CELLS, Acta oto-laryngologica, 116(2), 1996, pp. 273-276
This study was performed in order to determine the immunohistochemical
expression and distribution pattern as well as the electrophysiologic
al actions of substance P in human vestibular ganglion cells. Substanc
e P-like immunostaining was mainly found in the cytoplasm of small ves
tibular ganglion cells. In contrast, nerve fibers were not labelled. U
sing intracellular recording techniques, substance P produced a slow d
epolarization of membrane potentials accompanied by an increase in mem
brane resistance. Furthermore, an enhanced firing response to depolari
zation occurred.