PERIPHERAL-BLOOD PROGENITOR-CELL TRANSPLANTATION - A SINGLE-CENTER EXPERIENCE COMPARING 2 MOBILIZATION REGIMENS IN 67 PATIENTS

Citation
P. Mahendra et al., PERIPHERAL-BLOOD PROGENITOR-CELL TRANSPLANTATION - A SINGLE-CENTER EXPERIENCE COMPARING 2 MOBILIZATION REGIMENS IN 67 PATIENTS, Bone marrow transplantation, 17(4), 1996, pp. 503-507
Citations number
14
Categorie Soggetti
Hematology,Oncology,Immunology,Transplantation
Journal title
ISSN journal
02683369
Volume
17
Issue
4
Year of publication
1996
Pages
503 - 507
Database
ISI
SICI code
0268-3369(1996)17:4<503:PPT-AS>2.0.ZU;2-Q
Abstract
Between June 1991 and January 1995 we performed 67 peripheral blood pr ogenitor cell transplants (PBPCT), Ten patients (group 1) were mobilis ed with 7 gm/m(2) of cyclophosphamide followed by daily G-CSF injectio ns (5 mu g/kg, subcutaneously). When the white cell count reached 1 x 10(9)/l they were leukapheresed for 5 days, After stem cell infusion t hey received G-CSF (10 mu g/kg/day) until the neutrophil count reached 1.5 x 10(9)/l, Fifty-six patients had PBPCs mobilised with 3 gm/m(2) of cyclophosphamide followed by daily subcutaneous G-CSF (5 mu g/kg) a nd PBPCs were harvested on 2 consecutive days, when the white cell cou nt rose to 4 x 10(9)/l, After stem cell infusion this group did not re ceive G-CSF, In 47 of the 56 patients (group 2) adequate MNC (greater than or equal to 4 x 10(8)/kg) and/or CFU-GM (greater than or equal to 10 x 10(4)/kg) were obtained, Insufficient MNC and/or CFU-GM were obt ained in 10 patients, They were therefore transplanted using a combina tion of bone marrow and peripheral blood progenitor cells (group 3), O verall 64 patients successfully engrafted, Median days to neutrophils greater than or equal to 0.5 x 10(9)/l were 9 (range 8-13), 12 (range 8-25) and 11 (range 9-16) and to platelets greater than or equal to 50 x 10(9)/l were 11 (range 9-23), 13 (range 9-90) and 16 (range 13-99) in groups 1, 2 and 3 respectively, Patients in group 1 had a faster ne utrophil recovery than patients in group 2 (P = 0.0002), The three pat ients who failed to engraft all received a combination of autologous p eripheral blood and bone marrow cells.