7-(2'-DEOXY-ALPHA-D-RIBOFURANOSYL)HYPOXANTHINE

Authors
MARFURT J STULZ E TRAFELET HU ZINGG A LEUMANN C HAZENKAMP M JUDD R SCHENKER S STROUSE G WARD TR FORTSCH M HAUSER J BURGI HB
Citation
J. Marfurt et al., 7-(2'-DEOXY-ALPHA-D-RIBOFURANOSYL)HYPOXANTHINE, Acta crystallographica. Section C, Crystal structure communications, 52, 1996, pp. 713-716
Citations number
17
Categorie Soggetti
Crystallography
Journal title
Acta crystallographica. Section C, Crystal structure communications → ACNP
ISSN journal
01082701
Volume
52
Year of publication
1996
Part
3
Pages
713 - 716
Database
ISI
SICI code
0108-2701(1996)52:<713:7>2.0.ZU;2-7
Abstract
The alpha-configured N7 analogue of 2'-deoxyinosine [7-(2'-deoxy-alpha -D-ribofuranosyl)hypoxanthine, C10H12N4-O-4] shows the following struc tural characteristics: (i) the furanose part of the molecule adopts th e 2'-endo conformation [pseudorotation phase angle 166.4 (2)degrees]; (ii) the torsion angle chi (O4'-C1'-N7-C5) is syn [70.9 (1)degrees] wi th the base substituent pointing away from the sugar unit; (iii) the n ucleobases are not hydrogen bonded to each other; only sugar-base hydr ogen bonds between adjacent molecules were detected.