Three new pyrrolizidine alkaloids, echilumiline, pycananthine and echi
humiline N-oxide, were isolated from Echium humile and their structure
s determined by spectroscopic methods. In addition, we record the pres
ence of the known alkaloids, 7-senecioylretronecine, 9-senecioylretron
ecine, lycopsamine and 7-acetyl-lycopsamine. The tetrahydro-isoquinoli
ne alkaloid, carnegine, was reduced for the first time in the Boragina
ceae.