SYNTHETIC STUDIES OF NOVEL TREHALASE INHI BITOR, TREHAZOLIN AND ITS RELATED-COMPOUNDS

Total synthesis of the novel trehalase inhibitor, trehazolin was accom plished, and its absolute structure was determined. On the basis of th is synthetic study, several related compounds including its stereoisom ers were synthesized to investigate the effects of their stereochemist ry and framework on the enzyme inhibitory activities. Further studies were carried out for the syntheses and biological evaluation of the tr ehazolin derivatives, which were derived from its natural aminocyclito l and modified at the terminal amino group of trehalamine. They were d esigned as compounds exhibiting the inhibition toward the other glucos idases such as intestinal maltase and isomaltase, judging from the str uctural similarity between D-glucose and trehalamine.