Purpose: External photography and subjective response were used to eva
luate the use of botulinum A toxin to diminish glabellar kinetic folds
. Methods: Eleven patients with glabellar folds and midline forehead w
rinkling received one to four injections of 0.1 ml of 100 U/1 mi botul
inum A toxin. The injections were given into the procerus or corrugato
r muscles or both. The number of injections corresponded to the wrinkl
e lines in each patient. The patients were examined and photographed j
ust before the injections and at 7 to 10 days after the injections. Tr
eatment efficacy was judged by photographic evaluation and by the pati
ent's subjective evaluation of the effect of the treatment. Results: P
hotographic evaluation showed objective improvement in the glabellar w
rinkling in 6 of 11 patients in relaxed facial position and in all 11
patients during contraction of the periocular muscles. Ten of the 11 p
atients reported satisfaction with their cosmetic results and indicate
d that they would choose to have the procedure done again. Conclusions
: The results of this study suggest that botulinum A toxin is a safe a
nd effective treatment for glabellar folds.