INTRAOPERATIVE APPLICATION OF TOPICAL MITOMYCIN-C FOR PTERYGIUM SURGERY

Background: Postoperative recurrence of pterygium occurs in many patie nts. The authors studied the recurrence rate of pterygium after admini stration of a single intraoperative dosage of topical mitomycin C at t he completion of pterygium excision. Methods and Patients: Eighty-one patients underwent excision of pterygium, leaving the sclera bare. The first 60 patients were randomized into two treatment groups of 30 pat ients each. The remaining 21 patients were offered mitomycin C. Group 1 included 49 patients (30 randomized and 19 of the remaining 21 patie nts) who received an intraoperative application of 0.02% (0.2 mg/ml) m itomycin C for 5 minutes, and group 2 included 32 patients (30 randomi zed and 2 of the remaining 21 patients) who received NaCl 0.9% instead of mitomycin C. Patients were followed from 12 to 28 months in a mask ed manner. Results: The pterygium recurred in 2 (4%) of 49 patients in group 1 and in 15 (46.7%) of the 32 patients in group 2 (P = 0.0001). A delay of epithelialization for 5 and 10 weeks occurred in two patie nts in group 2 and granuloma manifested in one patient in group 1, Con clusion: This study indicates that intraoperative administration of a single dosage of 0.02% mitomycin C is an effective treatment for preve ntion of recurrence of pterygium.