Hs. Sader et al., OXACILLIN-RESISTANT AND QUINOLONE-RESISTANT STAPHYLOCOCCUS-AUREUS IN SAO-PAULO, BRAZIL - A MULTICENTER MOLECULAR EPIDEMIOLOGY STUDY, Infection control and hospital epidemiology, 14(5), 1993, pp. 260-264
OBJECTIVE: To investigate the possibility of interhospital spread of m
ultiresistant Staphylococcus aureus in Sao Paulo, Brazil. DESIGN: We e
valuated 13 nosocomial S aureus strains selected because of resistance
to oxacillin and ciprofloxacin. SETTING: The strains were collected b
etween March 1991 and September 1991 from four different hospitals in
Sao Paulo. Two were teaching hospitals, and two were private hospitals
. PATIENTS: Each strain was isolated from a different patient. All pat
ients were hospitalized when the strains were isolated. INTERVENTIONS:
The strains were typed by restriction endonuclease analyses of plasmi
d DNA (REAP) using EcoRI, HindIII, RsaI, and AluI and by extended anti
biogram profile (34 drugs). RESULTS: AH strains had identical plasmid
and antibiogram profile. They demonstrated the same plasmid pattern as
previously described in one of the hospitals studied. CONCLUSIONS: Ou
r results suggest the dissemination of a unique oxacillin- and quinolo
ne-resistant strain of S aureus in several hospitals of Sao Paulo, Bra
zil.