NECROTIZING CEREBRITIS IN AN ALLOGENEIC BONE-MARROW TRANSPLANT RECIPIENT DUE TO CLADOPHIALOPHORA-BANTIANA

We describe a necrotizing cerebritis in an allogeneic bone marrow tran splant recipient caused by the neurotropic, dematiaceous fungus Cladop hialophora bantiana. The patient presented 7 months after bone marrow transplantation with fever and sudden onset of left-sided weakness, fo llowed shortly by cranial nerve III and VI palsies. The patient had a lesion (3.0 by 2.0 by 2.0 cm) of the right midbrain with extension to the pens, the left brain stem, and the right superior and the middle c erebellar peduncles. The diagnosis was made by microscopic examination and culture of a brain biopsy.