SYNTHESIS, STRUCTURE, AND SPECTROSCOPIC PROPERTIES OF PYRIDINE-2-CARBALDEHYDETHIOSEMICARBAZONATO)TIN(IV) ACETIC-ACID SOLVATE, [SNME(2)(PYTSC)(OAC)]CENTER-DOT-HOAC - COMPARISON OF ITS BIOLOGICAL-ACTIVITY WITH THAT OF SOME STRUCTURALLY RELATED DIORGANOTIN(IV)BIS(THIOSEMICARBAZONATES)

The synthesis, X-ray structure, behavior in solution, and biological p roperties of the complex [SnMe(2)(PyTSC)(OAc)].HOAc (HPyTSC = pyridine -2-carbaldehydethiosemicarbazone) are reported. The tin atom of this c omplex is coordinated to an N,N,S-tridentate PyTSC(-) anion, to a mono dentate acetate ion, and to the two methyl groups in an approximately pentagonal bipyramidal environment with a vacant equatorial position. The complex partially evolves in DMSO and in DMSO/CHxCl4-x (X = 1, 2) mixtures, giving HPyTSC and SnMe(2)(OAc)(2). [SnMe(2) (PyTSC)(OAc)].HO Ac, [SnMe(2)(DAPTSC)], and [SnPh(2)(DAPTSC)].2DMF (H(2)DAPTSC = 2,6-di acetylpyridine bis(thiosemicarbazone)) all suppress proliferation of F riend erythroleukaemia cells (FLC). DMSO-induced differentiation of FL C is slightly suppressed by [SnMe(2)(DAPTSC)] and is unaffected by [Sn Ph(2)(DAPTSC)].2DMF and [SnMe(2)(PyTSC)(OAc)].HOAc.