MICRONUCLEI IN LYMPHOCYTES OF CHILDREN FROM THE VICINITY OF CHERNOBYLBEFORE AND AFTER I-131 THERAPY FOR THYROID-CANCER

The present study addresses the monitoring of children from the Beloru ssian and Ukrainian Republics exposed to the fall-out of the Chernobyl accident. Micronucleus analysis has been performed on 56 children fro m different areas. The micronucleus frequencies in individuals as well as in regional groups were comparable with controls, except for three donors. Such results had to be expected, taking into account that at least 7 years have passed since the accident. Most of the children who se micronucleus frequencies were determined are suffering from thyroid cancer and were treated by radioiodine (I-131) therapy. We studied th e effect of in vitro exposure with I-131 on micronucleus induction and that proliferative ability of lymphocytes. The present investigation indicates that micronuclei can be usefully employed to detect individu al exposures to the incorporated radionuclide within several days afte r the intake of the radionuclide in a dose range of around 65-390 mGy (effective dose).