K. Wuttke et al., MICRONUCLEI IN LYMPHOCYTES OF CHILDREN FROM THE VICINITY OF CHERNOBYLBEFORE AND AFTER I-131 THERAPY FOR THYROID-CANCER, International journal of radiation biology, 69(2), 1996, pp. 259-268
Citations number
42
Categorie Soggetti
Radiology,Nuclear Medicine & Medical Imaging","Nuclear Sciences & Tecnology
The present study addresses the monitoring of children from the Beloru
ssian and Ukrainian Republics exposed to the fall-out of the Chernobyl
accident. Micronucleus analysis has been performed on 56 children fro
m different areas. The micronucleus frequencies in individuals as well
as in regional groups were comparable with controls, except for three
donors. Such results had to be expected, taking into account that at
least 7 years have passed since the accident. Most of the children who
se micronucleus frequencies were determined are suffering from thyroid
cancer and were treated by radioiodine (I-131) therapy. We studied th
e effect of in vitro exposure with I-131 on micronucleus induction and
that proliferative ability of lymphocytes. The present investigation
indicates that micronuclei can be usefully employed to detect individu
al exposures to the incorporated radionuclide within several days afte
r the intake of the radionuclide in a dose range of around 65-390 mGy
(effective dose).