IN-VITRO DEGRADATION CHARACTERISTICS OF POLY(ANHYDRIDE-IMIDES) CONTAINING PYROMELLITYLIMIDOALANINE

Citation
Ke. Uhrich et al., IN-VITRO DEGRADATION CHARACTERISTICS OF POLY(ANHYDRIDE-IMIDES) CONTAINING PYROMELLITYLIMIDOALANINE, Journal of polymer science. Part A, Polymer chemistry, 34(7), 1996, pp. 1261-1269
Citations number
21
Categorie Soggetti
Polymer Sciences
ISSN journal
0887624X
Volume
34
Issue
7
Year of publication
1996
Pages
1261 - 1269
Database
ISI
SICI code
0887-624X(1996)34:7<1261:IDCOPC>2.0.ZU;2-9
Abstract
The in vitro degradation characteristics of poly(anhydride-imides) con taining pyromellitylimidoalanine, with either 1,6-bis(carboxyphenoxy)h exane (CPH) or sebacic acid (SA) were assessed. The copolymers contain ed up to 50 mol % of the imide monomer, pyromellitylimidoalanine (PMA- ala). Degradation was pH sensitive, being enhanced under basic conditi ons. Control of degradation times from 2 days to 2 months was achieved by the selection of appropriate monomer units in the polymer backbone . Monomers were chosen based on their solubility in aqueous media, as well as how they influenced the hydrophobicity and crystallinity of th e polymer matrices. Polymer degradation was followed by ultraviolet sp ectroscopy and high-pressure liquid chromatography. Increasing the amo unt of imide monomer, PMA-ala, and the use of SA (rather than CPH) as the comonomer increased the degradation rate of the polymer matrices. (C) 1996 John Wiley & Sons, Inc.