CHARACTERIZATION OF CENTCHROMAN BINDING-PROTEIN IN PLASMA OF RHESUS-MONKEY (MACACA-MULATTA)

Centchroman, a nonsteroidal antifertility agent was studied for its bi nding to monkey (Macaca mulatta) plasma proteins using charcoal adsorp tion and electrophoretic techniques. C-14-centchroman showed a low aff inity binding and did not compete for H-3-cortisol or H-3-DHT binding sites in plasma. C-14-centchroman binding protein was heat stable in n ature and showed the electrophoretic pattern similar to that of albumi n (Rf 0.70). Thus centchroman binds to albumin in monkey plasma which can be suggested as carrier protein for this contraceptive agent.