POTENTIAL-ENERGY FUNCTIONS FOR THREADING

Despite little progress in ab initio solutions to the problem of predi cting a protein's tertiary structure, over the past four years or so t he development of fold-recognition methods for tertiary structure pred iction has been the source of some encouragement in this difficult fie ld. Despite promising initial results, these methods are clearly not y et fully mature and many groups are now working on different aspects o f the methods involved in the hope of increasing the reliability and s ensitivity of these tools.