INCORPORATION OF UNNATURAL AMINO-ACID DERIVATIVES INTO A PEPTIDE-BONDVIA AN OXIME ESTER CATALYZED BY PAPAIN OR LIPASE

Authors
CHEN ST TSAI CF WANG KT
Citation
St. Chen et al., INCORPORATION OF UNNATURAL AMINO-ACID DERIVATIVES INTO A PEPTIDE-BONDVIA AN OXIME ESTER CATALYZED BY PAPAIN OR LIPASE, Chemical communications, (2), 1996, pp. 165-166
Citations number
21
Categorie Soggetti
Chemistry
Journal title
Chemical communications → ACNP
ISSN journal
13597345
Issue
2
Year of publication
1996
Pages
165 - 166
Database
ISI
SICI code
1359-7345(1996):2<165:IOUADI>2.0.ZU;2-H
Abstract
In the presence of an oxime in the reaction solution, papain and lipas e P (Pseudomonas from Amano) catalysed the stereoselective transesteri fication of an N-protected amino acid or peptide ester to form an acti ve (oxime) ester which in turn underwent peptide bond formation with s everal natural and unnatural amino acid derivatives (proline, N-methyl glycine, N-methylalanine, alpha-methylphenylalanine).