CHROMOSOMAL LOCALIZATION OF THE MAMMALIAN PEPTIDE-METHIONINE SULFOXIDE REDUCTASE GENE AND ITS DIFFERENTIAL EXPRESSION IN VARIOUS TISSUES

Authors
MOSKOVITZ J JENKINS NA GILBERT DJ COPELAND NG JURSKY F WEISSBACH H BROT N
Citation
J. Moskovitz et al., CHROMOSOMAL LOCALIZATION OF THE MAMMALIAN PEPTIDE-METHIONINE SULFOXIDE REDUCTASE GENE AND ITS DIFFERENTIAL EXPRESSION IN VARIOUS TISSUES, Proceedings of the National Academy of Sciences of the United Statesof America, 93(8), 1996, pp. 3205-3208
Citations number
27
Categorie Soggetti
Multidisciplinary Sciences
Journal title
Proceedings of the National Academy of Sciences of the United Statesof America → ACNP
ISSN journal
00278424
Volume
93
Issue
8
Year of publication
1996
Pages
3205 - 3208
Database
ISI
SICI code
0027-8424(1996)93:8<3205:CLOTMP>2.0.ZU;2-0
Abstract
Peptide methionine sulfoxide reductase (MsrA; EC 1.8.4.6) is a ubiquit ous protein that can reduce methionine sulfoxide residues in proteins as well as in a large number of methyl sulfoxide compounds, The expres sion of MsrA in various rat tissues was determined by using immunocyto chemical staining. Although the protein was found in all tissues exami ned, it,vas specifically localized to renal medulla and retinal pigmen ted epithelial cells, and it was prominent in neurons and throughout t he nervous system. In addition, blood and alveolar macrophages showed high expression of the enzyme, The msrA gene was mapped to the central region of mouse chromosome 14, in a region of homology with human chr omosomes 13 and 8p21.