THE BLOOD-BRAIN-BARRIER - PRINCIPLES FOR TARGETING PEPTIDES AND DRUGSTO THE CENTRAL-NERVOUS-SYSTEM

Authors
BEGLEY DJ
Citation
Dj. Begley, THE BLOOD-BRAIN-BARRIER - PRINCIPLES FOR TARGETING PEPTIDES AND DRUGSTO THE CENTRAL-NERVOUS-SYSTEM, Journal of Pharmacy and Pharmacology, 48(2), 1996, pp. 136-146
Citations number
46
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
Journal of Pharmacy and Pharmacology → ACNP
ISSN journal
00223573
Volume
48
Issue
2
Year of publication
1996
Pages
136 - 146
Database
ISI
SICI code
0022-3573(1996)48:2<136:TB-PFT>2.0.ZU;2-L
Abstract
The presence of the blood-brain barrier (BBB), reduces the brain uptak e of many drugs, peptides and other solutes from blood. Strategies for increasing the uptake of drugs and peptide-based drugs include; struc tural modifications to increase plasma half-life; improving passive pe netration of the BBB by increasing the lipophilicity of the molecule; designing drugs which react with transporters present in the BBB; and reducing turnover and efflux from the central nervous system (CNS).