The Y chromosomes of most Drosophila species are necessary for male fe
rtility but they are not involved in sex determination. They have many
puzzling properties that resemble the effects caused by B chromosomes
. Classical genetic and molecular studies reveal substantial affinitie
s between Y and B chromosomes and suggest that the Y chromosomes of Dr
osophila are not degenerated homologues of the X chromosomes, but rath
er that their Y chromosomes evolved as specialized supernumeraries sim
ilar to classical B chromosomes.