KINETIC AND THERMODYNAMIC CONTROL OF L-THREONINE ALDOLASE CATALYZED REACTION AND ITS APPLICATION TO THE SYNTHESIS OF MYCESTERICIN-D

Authors
SHIBATA K SHINGU K VASSILEV VP NISHIDE K FUJITA T NODE M KAJIMOTO T WONG CH
Citation
K. Shibata et al., KINETIC AND THERMODYNAMIC CONTROL OF L-THREONINE ALDOLASE CATALYZED REACTION AND ITS APPLICATION TO THE SYNTHESIS OF MYCESTERICIN-D, Tetrahedron letters, 37(16), 1996, pp. 2791-2794
Citations number
12
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
37
Issue
16
Year of publication
1996
Pages
2791 - 2794
Database
ISI
SICI code
0040-4039(1996)37:16<2791:KATCOL>2.0.ZU;2-T
Abstract
L-Threonine aldolase catalyzes the aldol condensation of gamma-benzylo xybutanal and glycine with high erythrolthreo selectivity under a kine tically controlled condition. The erythro product was used in the synt hesis of mycestericin D, a potent immunosupressant. Copyright (C) 1996 Elsevier Science Ltd