POLYMER-SUPPORTED SILYL ENOL ETHERS - SYNTHESIS AND REACTIONS WITH IMINES FOR THE PREPARATION OF AN AMINO ALCOHOL LIBRARY

Authors
KOBAYASHI S HACHIYA I SUZUKI S MORIWAKI M
Citation
S. Kobayashi et al., POLYMER-SUPPORTED SILYL ENOL ETHERS - SYNTHESIS AND REACTIONS WITH IMINES FOR THE PREPARATION OF AN AMINO ALCOHOL LIBRARY, Tetrahedron letters, 37(16), 1996, pp. 2809-2812
Citations number
32
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
37
Issue
16
Year of publication
1996
Pages
2809 - 2812
Database
ISI
SICI code
0040-4039(1996)37:16<2809:PSEE-S>2.0.ZU;2-1
Abstract
Polymer-supported silyl enol ethers (thioketene silyl acetals) were pr epared from chloromethyl copoly-(styrene-1%-divinylbenzene) resin. The silyl enol ethers reacted with imines in the presence of a catalytic amount of scandium triflate (Sc(OTf)(3)) to afford beta-amino thioeste rs, which were reduced to amino alcohols in good yields. These reactio ns provide a convenient method for the preparation of an amino alcohol library. Copyright (C) 1996 Elsevier Science Ltd