ASYMMETRIC HYDROGENATION OF ALPHA,BETA-UNSATURATED CARBOXYLIC-ACIDS IN SUPERCRITICAL CARBON-DIOXIDE

Authors
XIAO JL NEFKENS SCA JESSOP PG IKARIYA T NOYORI R
Citation
Jl. Xiao et al., ASYMMETRIC HYDROGENATION OF ALPHA,BETA-UNSATURATED CARBOXYLIC-ACIDS IN SUPERCRITICAL CARBON-DIOXIDE, Tetrahedron letters, 37(16), 1996, pp. 2813-2816
Citations number
20
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
37
Issue
16
Year of publication
1996
Pages
2813 - 2816
Database
ISI
SICI code
0040-4039(1996)37:16<2813:AHOACI>2.0.ZU;2-Y
Abstract
Hydrogenation of tiglic acid in supercritical CO2 catalyzed by a chira l H-8-BINAP-Ru(II) complex proceeds cleanly with cis stereochemistry t o afford 2-methylbutanoic acid in up to 89% ee and over 99% yield. Cop yright (C) 1996 Elsevier Science Ltd