Familial cases of Kaposi's sarcoma are exceedingly rare, We identified
an 85-year-old man with Kaposi's sarcoma, Multiple lesions were prese
nt on the feet. Previously, the man's 84-year-old sister presented wit
h similar lesions on the lower extremity, Both siblings were Lifelong
residents of the United States and were of English/German descent. Nei
ther had risk factors for infection with human immunodeficiency virus
(HIV), On histologic examination, lesions in both patients demonstrate
d vascular slits, hemorrhage, and dense aggregates of spindle cells wi
thin the dermis.