BENZYNE ADDITION TO N-ALKYL-4-HYDROXY-1-METHYLISOQUINOLINIUM SALTS - A NEW AND CONVENIENT SYNTHESIS OF (+ 0,11-DIHYDRO-5H-DIBENZO[A,D]CYCLOHEPTEN-5,10-IMINE (MK801)/

Authors
CONSTABLE KP BLOUGH BE CARROLL FI
Citation
Kp. Constable et al., BENZYNE ADDITION TO N-ALKYL-4-HYDROXY-1-METHYLISOQUINOLINIUM SALTS - A NEW AND CONVENIENT SYNTHESIS OF (+ 0,11-DIHYDRO-5H-DIBENZO[A,D]CYCLOHEPTEN-5,10-IMINE (MK801)/, Chemical communications, (6), 1996, pp. 717-718
Citations number
16
Categorie Soggetti
Chemistry
Journal title
Chemical communications → ACNP
ISSN journal
13597345
Issue
6
Year of publication
1996
Pages
717 - 718
Database
ISI
SICI code
1359-7345(1996):6<717:BATNS->2.0.ZU;2-#
Abstract
Addition of benzyne, generated by three different methods, to N-benzyl -4-hydroxy-1-methylisoquinolinium betaine provides N-benzyl-5-methyl-1 1-oxo-5H-dibenzo[a,d] cyclohepten-5,10-imine which can be converted to MK801.