ENDOPLASMIC-RETICULUM IS MISSING IN DENDRITIC SPINES OF PURKINJE-CELLS OF THE ATAXIC MUTANT RAT

Authors
DEKKEROHNO K HAYASAKA S TAKAGISHI Y ODA S WAKASUGI N MIKOSHIBA K INOUYE M YAMAMURA H
Citation
K. Dekkerohno et al., ENDOPLASMIC-RETICULUM IS MISSING IN DENDRITIC SPINES OF PURKINJE-CELLS OF THE ATAXIC MUTANT RAT, Brain research, 714(1-2), 1996, pp. 226-230
Citations number
20
Categorie Soggetti
Neurosciences
Journal title
Brain research → ACNP
ISSN journal
00068993
Volume
714
Issue
1-2
Year of publication
1996
Pages
226 - 230
Database
ISI
SICI code
0006-8993(1996)714:1-2<226:EIMIDS>2.0.ZU;2-R
Abstract
Dilute-opisthotonus (dop) is a spontaneous ataxic mutation in the rat, regulated by an autosomal recessive gene. Immunohistochemical stainin g with anti-inositol 1,4,5-trisphosphate receptor antibody and electro n microscopic examinations revealed that the endoplasmic reticulum in dendritic spines of Purkinje cell was missing in the ataxic rat. This could impair the intracellular signal transduction in the parallel fib er-Purkinje cell synapse, and be a cause of the seven ataxic movement.