SYNTHESIS OF A NOVEL GC-SPECIFIC COVALENT-BINDING DNA AFFINITY-CLEAVAGE AGENT BASED ON PYRROLOBENZODIAZEPINES (PBDS)

Authors
THURSTON DE MORRIS SJ HARTLEY JA
Citation
De. Thurston et al., SYNTHESIS OF A NOVEL GC-SPECIFIC COVALENT-BINDING DNA AFFINITY-CLEAVAGE AGENT BASED ON PYRROLOBENZODIAZEPINES (PBDS), Chemical communications, (4), 1996, pp. 563-565
Citations number
20
Categorie Soggetti
Chemistry
Journal title
Chemical communications → ACNP
ISSN journal
13597345
Issue
4
Year of publication
1996
Pages
563 - 565
Database
ISI
SICI code
1359-7345(1996):4<563:SOANGC>2.0.ZU;2-#
Abstract
A novel GC-selective pyrrolobenzodiazepine-EDTA conjugate is synthesiz ed that covalently binds to DNA at 5'-PuGPu sequences leading to site- specific cleavage.