PURPOSE: To use perspective volume rendering (PVR) of computed tomogra
phic (CT) and magnetic resonance (MR) imaging data sets to simulate en
doscopic views of human organ systems. MATERIALS AND METHODS: Perspect
ive views of helical CT and MR images were reconstructed from the data
, and tissues were classified by assigning color and opacity based on
their CT attenuation or MR signal intensity. ''Flight paths'' were con
structed through anatomic regions by defining key views along a spline
path. Twelve movies of the thoracic aorta (n = 3), tracheobronchial t
ree (n = 4), colon (n = 3), paranasal sinuses (n = 1), and shoulder jo
int (n 1) were generated to display images along the flight path. All
abnormal results were confirmed at surgery. RESULTS: PVR fly-through e
nabled evaluation of the full range of tissue densities, signal intens
ities, and their three-dimensional spatial relationships. CONCLUSION:
PVR is a novel way to present volumetric data and may enable noninvasi
ve diagnostic endoscopy and provide an alternate method to analyze vol
umetric imaging data for primary diagnosis.